Amikacin is a parenteral aminoglycoside antibiotic most commonly used to treat gram-negative and staphylococcal infections. Its use should be reserved for severe infections proven or strongly suspected to be resistant to first line antibiotics.
Metabolism and pharmacodynamics
- Half-life: 30 minutes to 2 hours
- Elimination: Renal
Mechanism of action and spectrum of activity
- Bactericidal; Concentration-dependent with significant post-antibiotic effect
- Irreversible binding to the 30S ribosomal subunit on susceptible bacteria, inhibiting protein synthesis
- Gram-negative aerobes and some gram-positive aerobes (Klebsiella, Proteus, Pseudomonas, Salmonella, Enterobacter, Serratia, Shigella, Mycoplasma, and Staphylococcus.
Advantage over other drugs in the same class (gentamicin)
- Improved activity against some strains of Pseudomonas aeruginosa, Serratia and Proteus spp.