Clopidogrel is an irreversible platelet aggregation inhibitor that is used in the prevention of arterial thromboembolism. Clopidogrel does not treat thromboembolism but may help prevent the formation of new clots during the course of a patient’s disease.
Crit Care Nurse 2008;28(10):26-40
Mechanism of action/pharmacokinetics
- Clopidogrel is a pro-drug that is metabolized in the liver and cytochrome p450 to an unstable active metabolite
- Inhibits the binding of ADP to the P2Y12 receptor on platelets, which prevents activation of the GPIIb/IIIa complex. The ADP receptor is permanently altered on the platelet affected.
- No pharmacokinetic data are available in veterinary species. In humans, bioavailability is 50% and food does not affect absorption.
- Mild, self-limiting diarrhea
- Hemorrhage, especially if coupled with other anticoagulants