Mycophenolate

Mycophenolate mofetil (MMF) is an immunosuppressive agent that inhibits both T- and B-cells. There is limited information in veterinary medicine. Mycophenolate is most commonly used as part of multi-modal therapy for a variety of immune-mediated diseases. The addition of MMF can sometimes reduce and eliminate the need for high-dose corticosteroids.

Injectable mycophenolate is a good option for conditions where oral administration of secondary immunosuppressive agents is not possible or not desired, for example due to vomiting/regurgitation or impaired mentation. Depending on response to treatment, patients may be switched to oral forms of the medication for longer-term management.

Dosing Recommendations

  • All uses are currently considered off-label in animals
  • 10-20 mg/kg IV q12

Researched uses include

IMHA, ITP, pemphigus foliaceus and other immune-mediated skin diseases, myasthenia gravis, meningoencephalitis, glomerular disease

References

  1. Barnoon, I., Shamir, M. H., Aroch, et al. (2016), Retrospective evaluation of combined mycophenolate mofetil and prednisone treatment for meningoencephalomyelitis of unknown etiology in dogs: 25 cases (2005–2011). Journal of Veterinary Emergency and Critical Care, 26: 116–124. doi:10.1111/vec.12399. Download article
  2. Cummings, F. O. and Rizzo, S. A. (2017), Treatment of presumptive primary immune-mediated thrombocytopenia with mycophenolate mofetil versus cyclosporine in dogs. J Small Anim Pract, 58: 96–102. doi:10.1111/jsap.12621. Download article
  3. Wang, A., Smith, J. R. and Creevy, K. E. (2013), Treatment of canine idiopathic immune-mediated haemolytic anaemia with mycophenolate mofetil and glucocorticoids: 30 cases (2007 to 2011). J Small Anim Pract, 54: 399–404. doi:10.1111/jsap.12107. Download article
  4. IRIS Canine GN Study Group Established Pathology Subgroup, Segev, G., Cowgill, L.D., Heiene, R., Labato, M.A. and Polzin, D.J. (2013), Consensus Recommendations for Immunosuppressive Treatment of Dogs with Glomerular Disease Based on Established Pathology. J Vet Intern Med, 27: S44–S54. doi:10.1111/jvim.12228. Download article

Additional resources

Last updated: 2017-08-11